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Anti-B2M Antibody Polyclonal
|B2M antibody was raised against a 15 amino acid peptide near the carboxy terminus of human B2M. |
||ELISA, WB: 1 - 2 ug/ml
|B2M Antibody is supplied in PBS containing 0.02% sodium azide.|
|B2M Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens beta-2-microglobulin (B2M)|
|beta chain of MHC class I molecules; beta-2-microglobin; beta-2-microglobulin|
|B2M Antibody: Beta2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system (1,2). B2M is involved in the presentation of peptide antigens to the immune system and plays a critically important role in immune system function (3). It is expressed on nearly all nucleated cells and contains one Ig-like C1-type (immunoglobulin-like) domain (2,3). Mutations in the Beta 2-microglobulin gene can enhance the progression of malignant melanoma and osteoarthropathy (4,5).|
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Western blot analysis of B2M in SK-N-SH cell lysate with B2M antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.