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Home Antibody All anti-POGZ antibodies

Anti-POGZ Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319377
  • Rabbit polyclonal anti-Pogz antibody
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenThis affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminus of mouse Pogz protein.
Clone Name IsotypeIgG
Species Reactivityhuman, dog, short-tailed opossum, bovine, rat, chimpanzee, macaque, olive baboon, chicken Concentration1.6 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:100,000 to 1:400,000, WB: 1:2,000 to 1:20,000
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. Pogz is a zinc-finger protein containing at least 8 C2H2 zinc fingers, a CENP-B (centromere protein-B) domain, and a DDE domain found in the bacterial transposase/retroviral integrase family. Members of this family of integrases share structural homologies and show similar catalytic activity to the RAG1 and RAG2 proteins that initiate V(D)J recombination in lymphoid progenitors.  Mouse Pogz has a human homolog with a base pair similarity of 90% and amino acid similarity of 93% for the full length protein.  In humans at least 3 variants have been predicted and they are all similar at the N-terminus.   A number of expressed sequence tags (ESTs) cloned from murine undifferentiated ES cells and Lin-/c-Kit+/Sca-1+ hematopoietic stem cell cDNA libraries correspond to the Pogz gene, further underlining an important function for this gene in stem cells.  In mice, deletion of the gene in all tissues early in embryogenesis has been shown to be lethal.

Reference Data

Target NameMus musculus pogo transposable element with ZNF domain (Pogz), transcript variant 1
Alternative Name9530006B08Rik; AU015913; AU044539
Database LinkNP_766271
Function
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot using affinity purified anti-Pogz antibody shows detection of Pogz protein (arrowhead) in adult mouse thymus and spleen tissue lysate (Panel A). The lower molecular weight bands may be cross reactive proteins. Pre-incubation of antibody with the immunizing peptide blocks specific antibody reactivity (Panel B). Primary antibody was used at 1:20,000. Personal Communication, K.O. Gudmundsson and J. Keller, NCI, Frederick, MD.

 

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