Home Antibody All anti-TGFB2 antibodies
Also for TGFB2 (NM_003238)
|E. coli expressed recombinant human TGF-ß2 |
|Human, mouse, rat
||WB: 0.5-4 ug/ml
|100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Homo sapiens transforming growth factor, beta 2 (TGFB2), transcript variant 2|
Entrez Gene 7042 Human
Entrez Gene 21808 Mouse
Entrez Gene 81809 Rat
|The three mammalian isoforms of TGF-beta (TGF-beta1, TGF-beta2, TGF-beta3) signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. |
|Secreted ProteinTransmembraneDruggable Genome MAPK signaling pathwayCytokine-cytokine receptor interactionCell cycleTGF-beta signaling pathwayPathways in cancerColorectal cancerMore Pathways >> |
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Western blot analysis using recombinant human TGF-beta2. Lane 1: 5 ng, Lane 2: 10 ng, Lane 3: 50 ng, Lane 4: 100 ng.