Home Antibody All anti-KCP antibodies
|CRIM2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human CRIM2.|
|Human, mouse, rat
||WB: 1-2 ug/ml, ELISA
|100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Affinity chromatography purified via peptide column
|Homo sapiens kielin/chordin-like protein (KCP), transcript variant 2|
|CRIM2; KCP1; NET67|
Entrez Gene 375616 Human
Entrez Gene 333088 Mouse
Entrez Gene 296952 Rat
|CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-ß1, suppressing activin- and TGF-ß1-dependent transcription.|
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Western blot analysis of CRIM2 in Jurkat cell lysate with CRIM2 antibody at (A) 1 and (B) 2 µg/ml.