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Home Antibody All anti-Dkk2 antibodies

Anti-Dkk2 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA318961 Rabbit polyclonal anti-DKK2 antibody 100ug $325 3-7 Days
LC402332 DKK2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)

OriGene Data

ImmunogenSynthetic peptide surrounding amino acid 241 of mouse Dkk2 (
Clone Name IsotypeRabbit IgG
Species ReactivityHuman, mouse, rat Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.5-4 ug/ml
Buffer100 µg (0.5 mg/ml) purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
Purification Affinity purified

Reference Data

Target NameHomo sapiens dickkopf WNT signaling pathway inhibitor 2 (DKK2)
Alternative NameDKK-2
Database LinkNP_055236
Entrez Gene 27123 Human
Entrez Gene 56811 Mouse
Entrez Gene 295445 Rat
FunctionXenopus Dickkopf (Dkk)-1 was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of Dkk have been identified in mammals. Each Dkk molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of Dkk1 and Dkk2 inhibited Wnt-3a-activated signaling, whereas the first Cys-rich domains had no effects. In addition, the second Cys-rich domain of Dkk-2, but not that of Dkk-1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl.
Related PathwayStem cell relevant signaling - Wnt Signaling pathwaySecreted ProteinES Cell Differentiation/IPSAdult stem cellsCancer stem cellsDruggable Genome Wnt signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Dkk2 expression in rat kidney tissue lysate.
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