Home Antibody All anti-Plaur antibodies
Also for Plaur (NM_002659)
|Synthetic peptide surrounding amino acid 51 of rat uPAR|
||Lot dependent; please refer to CoA along with shipment
||WB: 0.5-1 ug/ml
|100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in 1X phosphate-buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.|
|Homo sapiens plasminogen activator, urokinase receptor (PLAUR), transcript variant 1|
|CD87; U-PAR; UPAR; URKR|
Entrez Gene 50692 Rat
|uPAR (Urokinase plasminogen activator receptor) is a 55 kDa glycoprotein I-anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum ß-globulin, plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial tumor cells and are required for tumor invasion and metastasis.|
|Secreted ProteinDruggable Genome Complement and coagulation cascades|
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Western blot analysis of uPAR expression in rat kidney tissue lysate.