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Home Antibody All anti-OLR1 antibodies

Anti-OLR1 Antibody

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SKU Description Amount Price Availability*  
TA318943
  • Rabbit polyclonal anti-LOX-1 antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400904) , 20ug Explanation
100ug $325 In Stock
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WB(1)

OriGene Data

ImmunogenSynthetic peptide near the N-terminus of human Lox-1
Clone Name IsotypeRabbit IgG
Species ReactivityHuman, mouse, rat Concentration0.5mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.5-4 ug/ml, IHC: 5ug/ml
Buffer100 µg (0.5 mg/ml) affinity purified rabbit anti-LOX-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified

Reference Data

Target NameHomo sapiens oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant 1
Alternative NameCLEC8A; LOX1; LOXIN; SCARE1; SLOX1
Database LinkNP_002534
Entrez Gene 4973 Human
Entrez Gene 108078 Mouse
Entrez Gene 140914 Rat
FunctionLectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1), also known as oxidized low-density-lipoprotein receptor-1 (OLR-1), belongs to the C-type lectin family. LOX-1 binds and supports the internalization of multiple structurally unrelated macromolecules including oxidized LDL, advanced glycation end products (AGE), activated platelets, bacteria, apoptotic or aged cells, and heat shock proteins. Human LOX-1 gene encodes a 273 amino acid residues (aa) protein with a short N-terminal intracellular domain, a transmembrane domain, an extracellular stalk/neck region followed a C-type lectin-like domain (CTLD). The expression of LOX-1 is induced by proinflammatory or proatherogenic stimuli, as well as by oxidized LDL itself and hemodynamic or oxidative stress. LOX-1-dependent oxidized LDL uptake also induces apoptosis by inducing the expression of the pro-apoptotic Bax and downregulation of the anti-apoptotic Bcl-2.
Related PathwaySecreted ProteinTransmembraneDruggable Genome PPAR signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of LOX-1 expression in Jurkat cell lysate.
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