Home Antibody All anti-OLR1 antibodies
Also for OLR1 (NM_002543)
|Synthetic peptide near the N-terminus of human Lox-1|
|Human, mouse, rat
||WB: 0.5-4 ug/ml, IHC: 5ug/ml
|100 µg (0.5 mg/ml) affinity purified rabbit anti-LOX-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Homo sapiens oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant 1|
|CLEC8A; LOX1; LOXIN; SCARE1; SLOX1|
Entrez Gene 4973 Human
Entrez Gene 108078 Mouse
Entrez Gene 140914 Rat
|Lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1), also known as oxidized low-density-lipoprotein receptor-1 (OLR-1), belongs to the C-type lectin family. LOX-1 binds and supports the internalization of multiple structurally unrelated macromolecules including oxidized LDL, advanced glycation end products (AGE), activated platelets, bacteria, apoptotic or aged cells, and heat shock proteins. Human LOX-1 gene encodes a 273 amino acid residues (aa) protein with a short N-terminal intracellular domain, a transmembrane domain, an extracellular stalk/neck region followed a C-type lectin-like domain (CTLD). The expression of LOX-1 is induced by proinflammatory or proatherogenic stimuli, as well as by oxidized LDL itself and hemodynamic or oxidative stress. LOX-1-dependent oxidized LDL uptake also induces apoptosis by inducing the expression of the pro-apoptotic Bax and downregulation of the anti-apoptotic Bcl-2.|
|Secreted ProteinTransmembraneDruggable Genome PPAR signaling pathway|
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Western blot analysis of LOX-1 expression in Jurkat cell lysate.