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Home Antibody All anti-GNAI2 antibodies

Anti-GNAI2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA318889
  • Rabbit polyclonal anti-Gai2 antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400760) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for GNAI2 (NM_002070)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSynthetic peptide surrounding amino acid 229 of human Gai2
Clone Name IsotypeRabbit IgG
Species ReactivityHuman Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.5-4ug/ml, IP: 10-20ug/ml
Buffer100 µg (0.5 mg/ml) affinity-purified rabbit anti-Gai2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified

Reference Data

Target NameHomo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 1
Alternative NameGIP; GNAI2B; H_LUCA15.1; H_LUCA16.1
Database LinkNP_002061
FunctionGai2 is a 40-41 kDa alpha-subunit of heterotrimeric protein that shares sequence homology with Gai3 and Gai1. All these G proteins can be ADP-ribosylated at the carboxy terminal Cys of the CAAX sequence, interfering with receptor coupling. Gai2 is expressed widely in tissues and cell lines. Activation of PLC-ß by Gai-coupled receptors is the result of release of Gßg subunits from Gai. Gai2 regulates potassium channel activation. Mutation at Arg179 has been identified in tumors. This and the Q205L mutant inhibit adenylyl cyclase.
Related Pathway
Hemostasis
Melanogenesis
Signaling by GPCR

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WB Image
Western blot analysis of G alpha i2 expression in 3T3 cell lysate.

 

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