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Home Antibody All anti-PPP3CB antibodies

Anti-PPP3CB Antibody


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SKU Description Amount Price Availability*  
TA318865 Rabbit polyclonal anti-Calcineurin A antibody 100ug $482 3-7 Days
LC412072 PPP3CB HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenSynthetic peptide corresponding to residues surrounding amino acids 267 of human Calcineurin A
Clone Name IsotypeRabbit IgG
Species ReactivityHuman, mouse, rat, hamster, rabbit, bovine Concentration0.2 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1-4ug/ml, IP: 10-20ug/ml
Buffer100 µg (0.2 mg/ml) affinity purified, rabbit anti-Calcineurin A polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified

Reference Data

Target Nameprotein phosphatase 3 catalytic subunit beta
Alternative NameCALNA2|CALNB|CNA2|PP2Bbeta
Database LinkNP_066955
Entrez Gene 5532 Human
Entrez Gene 19056 Mouse
Entrez Gene 24675 Rat
FunctionCalcineurin is a calcium/calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit of 61 kDa and a myristylated regulatory B subunit of 19 kDa that binds calcium. The catalytic A subunit consists of an amino terminal catalytic domain, followed by calmodulin and B subunit binding sites, and a caboxyl-terminal autoinhibitory domain. Calnineurin is the target of immunosuppressant drugs such as cyclosporin A and FK506. Calcineurin controls the translocation of nuclear factors of activated T cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T cells. Calcineurin has been proposed to play an important role in mediating calcium-activated cell death.
Related PathwayPhosphataseTranscription FactorsDruggable Genome MAPK signaling pathwayCalcium signaling pathwayOocyte meiosisApoptosisWnt signaling pathwayAxon guidanceMore Pathways >>

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WB Image
Western blot analysis of Calcineurin A in lysate from Jurkat cells (Lane 1) and rat kidney (Lane 2).


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