TLR-7 is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and they mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR-7 is predominantly expressed in lung, placenta, and spleen (1).
Toll-like receptor signaling pathway
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