Anti-SETD7 Antibody, EPR5574

Also for SETD7 (NM_030648)

Gene Name	Homo sapiens SET domain containing (lysine methyltransferase) 7 (SETD7)
Synonyms:	KMT7; SET7; SET7/9; SET9
Immunogen	A synthetic peptide corresponding to residues in human SET7 / SET9 was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR5574	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:1,000 - 10,000;
Background	SET7/ SET9 is a histone methyltransferase that can monomethylate Lysine 4 of histone H3 and regulate protein expression (1, 2). This methylation represents a specific tag for epigenetic transcriptional activation. SET7/ SET9 plays a central role in the activation of proteins such as collagenase or insulin. It is recruited by IPF1/PDX-1 to the insulin promoter, activating transcription. Moreover, SET7/ SET9 has methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (2).
Related Pathway

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WB Image

Western blot analysis on (A) HeLa, (B) BxPC-3, (C) Jurkat, (D) MCF-7, (E) C6, (F) RAW264.7, (G) PC-12, and (H) NIH/3T3 cell lysates using anti-SET7 / SET9 RabMAb.

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Anti-SETD7 Antibody EPR5574

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