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Home Antibody All anti-SERPINB3 antibodies

Anti-SERPINB3 Antibody EPR5157

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA311061
  • Rabbit Monoclonal antibody against SCCA (SERPINB3)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC416321) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(3)
Assay(1)
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Also for SERPINB3 (NM_006919)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus in human SCCA was used as an immunogen.
Clone NameEPR5157 IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsICC/IF: 1:50 - 1:100; WB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 3 (SERPINB3)
Alternative NameHsT1196; SCC; SCCA-1; SCCA-PD; SCCA1; T4-A
Database LinkNP_008850
FunctionSCCA (Squamous cell carcinoma antigen) is a tumor marker antigen associated with cervical cancer that has served as a diagnostic serum marker for squamous cell carcinomas of the cervix, head, neck, and lung (1). It is a member of the serpin superfamily and fundamental for the control of proteolysis through a known inhibitory function of different proteases (2). SCCA is an atypical serpin in that it exhibits cross-class activity, inhibiting papain-like cysteine proteases (cathepsins L, K, and S) rather than serine proteases as targeted by most family members (1). It also plays a role in the modulation of apoptosis by different mechanisms, both in inflammatory processes and cancer. In particular, SCCA significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells (3).
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-SerpinB3 antibody [EPR5157]; All lanes : Anti-SerpinB3 antibody [EPR5157] at 1/1000 dilution.Lane 1 : A431 cell lysate.Lane 2 : Human fetal skin lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 45 kDa.Observed band size : 39 kDa .
Assay Image
Other-Anti-SerpinB3 antibody [EPR5157](TA311061); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SerpinB3 antibody [EPR5157]; TA311061, at 1/250 dilution, staining SerpinB3 in paraffin-embedded Human cervical carcinoma tissue by Immunohistochemistry.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-SerpinB3 antibody [EPR5157](TA311061); TA311061 showing positive staining in Normal tonsil squamous cells tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-SerpinB3 antibody [EPR5157](TA311061); TA311061 showing positive staining in Lung squamous cell carcinoma tissue.

 

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