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Anti-POLE3 Antibody EPR6300

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues at the C-terminus of human POLE was used as an immunogen.
Clone Name	EPR6300	Isotype
Species Reactivity	Human	Concentration
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:1,000 - 10,000; IHC 1:50 - 100; ICC: 1:50 - 100;
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens polymerase (DNA directed), epsilon 3, accessory subunit (POLE3), transcript variant 1
Alternative Name	CHARAC17; CHRAC17; p17; YBL1
Database Link	NP_059139
Function	DNA polymerases (pol) play essential roles in chromosomal DNA replication and repair. POLE is a proofreading DNA polymerase, which has been implicated in DNA replication. Moreover, it is associated with origins of DNA replication and it proceeds along the replication fork. In human cells, POLE is associated with actively replicated cellular DNA and has been shown to perform an important fraction of replicative DNA synthesis (1).
Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of polymerase (DNA directed), epsilon 3 (p17 subunit) (POLE3) Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • POLE3 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • POLE3 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Pole3 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • POLE3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Pole3 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens polymerase (DNA directed), epsilon 3 (p17 subunit) (POLE3) as transfection-ready DNA • Lenti ORF clone of Human polymerase (DNA directed), epsilon 3 (p17 subunit) (POLE3) , Myc-DDK-tagged • GFP-tagged ORF clone of Homo sapiens polymerase (DNA directed), epsilon 3 (p17 subunit) (POLE3) as transfection-ready DNA • Lenti ORF clone of Human polymerase (DNA directed), epsilon 3 (p17 subunit) (POLE3), mGFP tagged Related cDNA Clones • Homo sapiens polymerase (DNA directed), epsilon 3 (p17 subunit) (POLE3) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)