OS-9 is a lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). It binds terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation (1). OS-9 is highly expressed in osteosarcomas, which binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits (2).
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