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Anti-OS9 Antibody EPR4272(2)
Also for OS9 (NM_001017956)
|A synthetic peptide corresponding to residues near the C-terminus of human OS-9 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt.
|Homo sapiens osteosarcoma amplified 9, endoplasmic reticulum lectin (OS9), transcript variant 2|
|OS-9 is a lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). It binds terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation (1). OS-9 is highly expressed in osteosarcomas, which binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits (2).|
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Western blot - OS9 antibody [EPR4272(2)]; All lanes : Anti-OS9 antibody [EPR4272(2)] at 1/10000 dilution.Lane 1 : NIH3T3 cell lysate.Lane 2 : 293T cell lysate.Lane 3 : HL-60 cell lysate.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 76 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - OS9 antibody [EPR4272(2)]; Immunohistochemical analysis of paraffin-embedded Mouse testis tissue using ab109510 at a dilution of 1/100.