Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
WIPI2 is a member of the WIPI subfamily of WD40 repeat proteins. It has a 7-bladed propeller structure and contains a conserved motif for interaction with phospholipids (1). WIPI2 is an early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. This protein is ubiquitously expressed; Higher expression in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors (2).
Related Pathway
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Western blot analysis on (A) human placenta, (B) human pancreas, (C) JAR, (D) fetal heart, (E) Saos-2, (F) BxPC-3, and (G) Caco-2 cell lysates using anti-WIPI2 RabMAb.
