WIPI2 is a member of the WIPI subfamily of WD40 repeat proteins. It has a 7-bladed propeller structure and contains a conserved motif for interaction with phospholipids (1). WIPI2 is an early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. This protein is ubiquitously expressed; Higher expression in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors (2).
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