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Anti-USP28 Antibody EPR4249(2)
Also for USP28 (NM_020886)
|A synthetic peptide corresponding to residues in human USP28 was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IF
||WB: 1:1000 - 1:10000; ICC/IF: 1:50 - 1:100
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens ubiquitin specific peptidase 28 (USP28), transcript variant 1|
Entrez Gene 57646 Human
|The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (1). USP28 is a deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. It plays a role in DNA damage induced by apoptosis by specifically deubiquitinating proteins of the DNA damage pathway, such as CLSPN. USP28 is also involved in G2 DNA damage checkpoint by deubiquitinating CLSPN, thus preventing its degradation by the anaphase promoting complex/cyclosome (APC/C) (2).|
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Western blot - Anti-USP28 antibody [EPR4249(2)]; All lanes : Anti-USP28 antibody [EPR4249(2)] at 1/1000 dilution.Lane 1 : 293T cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : HT1376 cell lysate.Lane 4 : Human heart tissue lysate.Lane 5 : SW480 cell lysate.Lane 6 : A431 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 122 kDa.
Other-Anti-USP28 antibody [EPR4249(2)](TA310935); Equilibrium disassociation constant (KD)..
Immunocytochemistry/ Immunofluorescence - Anti-USP28 antibody [EPR4249(2)]; TA310935 at 1/50 dilution staining USP28 in HeLa cells by Immunofluorescence.