Anti-TPO Antibody, EPR5379

Also for TPO (NM_000547)

Gene Name	Homo sapiens thyroid peroxidase (TPO), transcript variant 1
Synonyms:	MSA; TDH2A; TPX
Immunogen	A synthetic peptide corresponding to residues in the extracellular domain in human TPO was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR5379	Isotype
Species Reactivity	Human	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:1,000 - 10,000; IHC 1:250 - 500; ICC: 1:100 - 250;
Background	TPO is a membrane-bound glycoprotein. It acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in TPO are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA (1).
Related Pathway	Cytokine-cytokine receptor interaction Hematopoietic cell lineage Jak-STAT signaling pathway

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WB Image

Western blot analysis on human thyroid lysate using anti-TPO RabMAb.

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Anti-TPO Antibody EPR5379

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