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Home Antibody All anti-TBC1D4 antibodies

Anti-TBC1D4 PHOSPHO Antibody EPR2733(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310893
  • Rabbit Monoclonal antibody against AS160, pT642 (TBC1D4) (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
Assay(1)
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Also for TBC1D4 (NM_014832)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Threonine 642 of human AS160 was used as an immunogen. This antibody only detects AS160 phosphorylated at Threonine 642.
Clone NameEPR2733(2) IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY Suggested DilutionsWB: 1:1000 - 1:10000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens TBC1 domain family, member 4 (TBC1D4), transcript variant 1
Alternative NameAS160
Database LinkNP_055647
Entrez Gene 9882 Human
FunctionAS160 is a Rab GTPase-activating protein (GAP) that is part of a subfamily of Rab GAPs that contain a conserved TBC1 (Tre-2/Bub2/Cdc16) domain (1). It is a negative regulator of GLUT4 vesicle translocation to the plasma membrane. The phosphorylation of TBC1D4 suppresses its GAP activity, thereby triggering docking of GLUT4 vesicles (2). AS160 is phosphorylated at multiple sites including Threonine 642. Insulin and IGF-1 induce 14-3-3 binding to AS160 mainly via phospho-Threonine 642 (3).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-TBC1D4 (phospho T642) antibody [EPR2733(2)]; All lanes : Anti-TBC1D4 (phospho T642) antibody [EPR2733(2)] at 1/1000 dilution.Lane 1 : 293T cell lysate - untreated.Lane 2 : 293T cell lysate - insulin-treated.Predicted band size : 146 kDa.
Assay Image
Other-Anti-TBC1D4 (phospho T642) antibody [EPR2733(2)](TA310893); Equilibrium disassociation constant (KD)..

 

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