TACC3 (Transforming acidic coiled-coil-containing protein 3) plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. It is involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors, and it also controls cell growth and differentiation. TACC3 is up-regulated in various cancer cell lines, suggesting that it may contribute to cancer (1).
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