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Home Antibody All anti-SMG5 antibodies

Anti-SMG5 Antibody EPR3503(2)

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA310860 Rabbit Monoclonal antibody against SMG5 100ul $325 In Stock
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WB(1)
IHC(2)
IF(1)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human SMG5 was used as an immunogen.
Clone NameEPR3503(2) IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
BufferpH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens SMG5 nonsense mediated mRNA decay factor (SMG5)
Alternative NameEST1B; LPTS-RP1; LPTSRP1; SMG-5
Database LinkNP_056142
Entrez Gene 23381 Human
FunctionSMG5 is an essential factor in nonsense-mediated mRNA decay, a conserved pathway that degrades mRNAs with premature translation termination codons. Phosphorylated UPF1 is directly recognized by SMG5, SMG6 and SMG7 via a conserved 14-3-3 like domain present in all three proteins. These proteins are thought to serve as adaptors between phosphorylated UPF1 and protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (1).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Western blot - Anti-SMG5 antibody [EPR3503(2)]; All lanes : Anti-SMG5 antibody [EPR3503(2)] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : 293T cell lysate.Lane 3 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 114 kDa.
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IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMG5 antibody [EPR3503(2)]; TA310860, at 1/100 dilution, staining SMG5 in Paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry.
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IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMG5 antibody [EPR3503(2)]; TA310860, at 1/100 dilution, staining SMG5 in Paraffin-embedded Human thyroid gland carcinoma tissue by Immunohistochemistry.
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IF Image
Immunocytochemistry/ Immunofluorescence - Anti-SMG5 antibody [EPR3503(2)]; TA310860, at 1/100 dilution, staining SMG5 in 293T cells by Immunofluorescence.
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