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Home Antibody All anti-SF3A1 antibodies

Anti-SF3A1 Antibody EPR7666

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310843
  • Rabbit Monoclonal antibody against SF3A1
100ul 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human SF3A1 was used as an immunogen.
Clone NameEPR7666 IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100
Predicted MW Explanation 89 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens splicing factor 3a, subunit 1, 120kDa (SF3A1), transcript variant 2
Alternative NamePRP21; PRPF21; SAP114; SF3A120
Database LinkNP_001005409
Entrez Gene 10291 Human
FunctionSF3A1 is subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. SF3A1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. It has tandemly repeated SURP motifs in its amino-terminal half, while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated SF3A1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3, while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs (1).
Related PathwayDruggable Genome Spliceosome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-SF3A1 antibody [EPR7666]; All lanes : Anti-SF3A1 antibody [EPR7666] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Lymph node lysate.Lane 3 : K562 cell lysate .Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 89 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SF3A1 antibody [EPR7666]; TA310843, at a 1/50 dilution, staining SF3A1 in paraffin embedded Human breast tissue by Immunohistochemistry.

 

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