Mutations in the Schizosaccharomyces pombe RAE1 and Saccharomyces cerevisiae Gle2 have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that RAE1 are involved in RNA export. It is a homolog of yeast Rae1. It contains four WD40 motifs and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm.RAE1 is thought to be involved in nucleocytoplasmic transport and directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton (1).
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