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Anti-PRKDC Phospho Antibody EPR5670
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for PRKDC (NM_001081640)
|A phospho specific peptide corresponding to residues surrounding Serine 2056 of human DNA-PK/PRKDC was used as an immunogen. This antibody only detects DNA-PK/PRKDC phosphorylated at Serine 2056.|
||WB: 1:1,000 - 10,000;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens protein kinase, DNA-activated, catalytic polypeptide (PRKDC), transcript variant 2|
|DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350; XRCC7|
|DNA-activated serine/threonine protein kinase (DNA-PK) is a nuclear protein kinase that is involved in DNA nonhomologous end joining (NHEJ) required for double- strand brake repair and V(D)J recombination. DNA-PK is composed of a large catalytic subunit of ~470 kDa (DNA-PKcs) and a DNA binding heterodimer of approximately 70- and 80-kDa subunits called Ku. (1-2). Autophosphorylation of DNA-PK correlates with loss of protein kinase activity and dissociation of the DNA-PKcs-Ku complex. DNA-PK phosphorylates Hsp90, p53 and c-Jun (3-4).|
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Western blot analysis on Jurkat cell lysates using anti-Phospho-DNA-PK/PRKDC (pS2056) RabMAb. Cells were either (A) untreated (B) treated with Alkaline Phosphatase.
Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-Phospho-DNA-PK/PRKDC (pS2056) RabMAb.