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Home Antibody All anti-PRKDC antibodies

Anti-PRKDC PHOSPHO Antibody EPR5670

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA310779
  • Rabbit Monoclonal antibody against DNA-PK/PRKDC (pS2056) (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
IHC(1)
Assay(1)
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Also for PRKDC (NM_006904)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Serine 2056 of human DNA-PK/PRKDC was used as an immunogen. This antibody only detects DNA-PK/PRKDC phosphorylated at Serine 2056.
Clone NameEPR5670 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for ICC or IP.

Reference Data

Target NameHomo sapiens protein kinase, DNA-activated, catalytic polypeptide (PRKDC), transcript variant 1
Alternative NameDNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; IMD26; p350; XRCC7
Database LinkNP_008835
Entrez Gene 5591 Human
FunctionDNA-activated serine/threonine protein kinase (DNA-PK) is a nuclear protein kinase that is involved in DNA nonhomologous end joining (NHEJ) required for double- strand brake repair and V(D)J recombination. DNA-PK is composed of a large catalytic subunit of ~470 kDa (DNA-PKcs) and a DNA binding heterodimer of approximately 70- and 80-kDa subunits called Ku. (1-2). Autophosphorylation of DNA-PK correlates with loss of protein kinase activity and dissociation of the DNA-PKcs-Ku complex. DNA-PK phosphorylates Hsp90, p53 and c-Jun (3-4).
Related PathwayProtein KinaseDruggable Genome Non-homologous end-joiningCell cycle

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-DNA PK (phospho S2056) antibody [EPR5670]; All lanes : Anti-DNA PK (phospho S2056) antibody [EPR5670] at 1/1000 dilution.Lane 1 : Jurkat cell lysate, untreated.Lane 2 : Jurkat cell lysate, treated with alkaline phosphatase.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 469 kDa.
Assay Image
Other-Anti-DNA PK (phospho S2056) antibody [EPR5670](TA310779); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DNA PK (phospho S2056) antibody [EPR5670]; TA310779, at 1/100 dilution, staining DNA PK in paraffin embedded Human brain tissue by immunohistochemistry.

 

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