PPBP is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. PPBP also stimulates the formation and secretion of plasminogen activator by synovial cells (1).
Cytokine-cytokine receptor interaction
Signaling by GPCR
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