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Anti-ABCD3 Antibody EPR5614


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SKU Description Amount Price Availability*  
TA310768 Rabbit Monoclonal antibody against PMP70 100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus in human PMP70 was used as an immunogen.
Clone NameEPR5614 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, Assay, FC Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:100 - 1:250; FC: 1:100 - 1:500
Predicted MW Explanation 75 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameATP binding cassette subfamily D member 3
Alternative NameABC43|CBAS5|PMP70|PXMP1|ZWS2
Database LinkNP_001116146
Entrez Gene 5825 Human
Entrez Gene 19299 Mouse
Entrez Gene 25270 Rat
FunctionPMP70 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). PMP70 is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters, which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations in PMP70 have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders (1).
Related PathwayTransmembraneDruggable Genome ABC transporters

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PMP70 antibody [EPR5614]; All lanes : Anti-PMP70 antibody [EPR5614] at 1/1000 dilution.Lane 1 : 293T cell lysate.Lane 2 : SH SY5Y cell lysate.Lane 3 : Caco2 cell lysate.Lane 4 : HepG2 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 75 kDa.Observed band size : 70 kDa .

Assay Image
Other-Anti-PMP70 antibody [EPR5614](TA310768); Equilibrium disassociation constant (KD)..

FC Image
Flow Cytometry - PMP70 antibody [EPR5614]; TA310768 at 1/100 dilution staining PMP70 in permeabilized HepG2 cells by Flow cytometry (shown in red). Rabbit IgG negative control (shown in green).


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