Homo sapiens promyelocytic leukemia (PML), transcript variant 6
Synonyms:
MYL; PP8675; RNF71; TRIM19
Immunogen
A phospho specific peptide corresponding to residues surrounding Serine 518 of human PML was used as an immunogen. This antibody only detects PML phosphorylated at Serine 518.
Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. PML is often involved with retinoic acid receptor alpha associated with acute promyelocytic leukemia (APL) (1).
Related Pathway
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Western blot analysis on HeLa cell lysates using anti-Phospho-PML (pS518) RabMAb. Cells were either (A) untreated or (B) treated with Alkaline Phosphatase.
