Anti-PF4 Antibody, EPR7762

Also for PF4 (NM_002619)

Gene Name	Homo sapiens platelet factor 4 (PF4)
Synonyms:	CXCL4; PF-4; SCYB4
Immunogen	A synthetic peptide corresponding to residues in human PF4 was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR7762	Isotype
Species Reactivity	Human, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:1,000 - 10,000;
Background	PF4, or Platelet factor-4, is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (1).
Related Pathway	Cytokine-cytokine receptor interaction Hemostasis Signaling by GPCR

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WB Image

Western blot analysis on (A) human spleen and (B) human platelet lysates using anti-PF4 RabMAb.

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Anti-PF4 Antibody EPR7762

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