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Home Antibody All anti-PDX1 antibodies

Anti-PDX1 Antibody EPR3358(2)

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SKU Description Amount Price Availability*  
TA310748
  • Rabbit Monoclonal antibody against PDX1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400074) , 20ug Explanation
100ul $325 3-7 Days
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WB(1)
IHC(6)
Assay(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus in human PDX1 was used as an immunogen.
Clone NameEPR3358(2) IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:1000 - 1:5000; ICC/IF: Use at an assay dependent concentration
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 40% Glycerol, 0.05% BSA, 59% PBS
Purification Protein A purified
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens pancreatic and duodenal homeobox 1 (PDX1)
Alternative NameGSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; STF-1
Database LinkNP_000200
Entrez Gene 3651 Human
FunctionPDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin expression. Defects in PDX1 are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of young type 4 (MODY4) (1).
Related PathwayES Cell Differentiation/IPSEmbryonic stem cellsInduced pluripotent stem cellsTranscription Factors Type II diabetes mellitusMaturity onset diabetes of the young

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-PDX1 antibody [EPR3358(2)]; All lanes : Anti-PDX1 antibody [EPR3358(2)] at 1/1000 dilution.Lane 1 : CACO-2 cell lysates.Lane 2 : BxPC-3 cell lysates.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 30 kDa.
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Other-Anti-PDX1 antibody [EPR3358(2)](TA310748); Equilibrium disassociation constant (KD)..
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDX1 antibody [EPR3358(2)]; Immunohistochemical analysis of paraffin embedded Human pancreas tissue labelled with TA310748 at 1/1000 dilution.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDX1 antibody [EPR3358(2)]; Immunohistochemical analysis of paraffin embedded Human duodenum tissue labelled with TA310748 at 1/1000 dilution.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDX1 antibody [EPR3358(2)]; TA310748 stainingPDX1 inHuman pancreas tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 5% serum for1 hourat 24°C; antigen retrieval was by heat mediation in10mM sodiumcitrate, pH 6.0. Samples were incubated with primary antibody (1/1000 in2% BSA) for 16 hours at 4°C. An Alexa Fluor? 488-conjugated Donkey anti-rabbit IgG polyclonal (1/400) was used as the secondary antibody.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-PDX1 antibody [EPR3358(2)](TA310748); Immunohistochemical analysis of paraffin embedded Human Colonic adenocarcinoma tissue using TA310748 showing +ve staining.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-PDX1 antibody [EPR3358(2)](TA310748); Immunohistochemical analysis of paraffin embedded Human Heart muscles tissue using TA310748 showing -ve staining.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-PDX1 antibody [EPR3358(2)](TA310748); Immunohistochemical analysis of paraffin embedded normal Human Normal brain tissue using TA310748 showing -ve staining.
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