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Home Antibody All anti-NUDT5 antibodies

Anti-NUDT5 Antibody EPR7734

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310733
  • Rabbit Monoclonal antibody against NUDT5
  • FREE positive control: HEK293T cell transient overexpression lysate (LC415472) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(2)
Assay(1)
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Also for NUDT5 (NM_014142)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human NUDT5 was used as an immunogen.
Clone NameEPR7734 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100; FC: 1:100 - 1:500
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC/IF or IP.

Reference Data

Target NameHomo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 5 (NUDT5)
Alternative NamehYSAH1; YSA1; YSA1H; YSAH1
Database LinkNP_054861
FunctionNudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (1). NUDT5 belongs to the Nudix (nucleoside diphosphate linked to another moiety X) hydrolase superfamily of versatile enzymes that are defined by their consensus MutT signature. NUDT5 hydrolyzes 8-oxo-dGDP, 8-oxo-GDP, 8-oxo-dADP, 2-oxo-dADP and 5-CHO-dUDP into their corresponding nucleoside monophosphates and inorganic phosphates. Since 8-oxo-dGDP inhibits hMTH1 activity, the catalytic activity of hNUDT5 also results in the promotion of hMTH1 activity as well as in a reduction in the amount of 8-oxo-dGTP generated from 8-oxo-dGDP by nucleoside diphosphate kinase. Thus, NUDT5 has a role in preventing replicational and transcriptional errors in human cells (2).
Related Pathway

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WB Image
Western blot - Anti-NUDT5 antibody [EPR7734]; All lanes : Anti-NUDT5 antibody [EPR7734] at 1/1000 dilution.Lane 1 : U937 cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : 293T cell lysate.Lane 4 : HepG2 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 24 kDa.
Assay Image
Other-Anti-NUDT5 antibody [EPR7734](TA310733); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUDT5 antibody [EPR7734]; TA310733, at a 1/50, staining NUDT5 in paraffin embedded Human kidney tissue by Immunohistochemistry.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUDT5 antibody [EPR7734]; TA310733, at 1/50, staining NUDT5 in paraffin embedded Human bladder carcinoma tissue by Immunohistochemistry.

 

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