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Anti-MVK Antibody EPR6507
|A synthetic peptide corresponding to residues in human MVK was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, FC
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:10 - 1:100
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA|
|Is unsuitable for ICC/IF or IHC-P.
|Homo sapiens mevalonate kinase (MVK), transcript variant 1|
|LRBP; MK; MVLK; POROK3|
Entrez Gene 4598 Human
|MVK is the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of MVK results in mevalonic aciduria, a disease characterized by psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in MVK also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash (1). |
|Druggable Genome Terpenoid backbone biosynthesisMetabolic pathways|
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Western blot - Anti-MVK antibody [EPR6507]; All lanes : Anti-MVK antibody [EPR6507] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : Caco-2 cell lysate.Lane 4 : Human fetal liver lysate.Lysates/proteins at 10 ug per lane.Secondary.Standard HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 42 kDa.Observed band size : 42 kDa.
Other-Anti-MVK antibody [EPR6507](TA310705); Equilibrium disassociation constant (KD)..
Flow Cytometry - Anti-MVK antibody [EPR6507]; TA310705, at a 1/10 dilution, positively staining MVK in permeabilized HepG2 cells (red). A Rabbit IgG was used as negative control (green).