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Home Antibody All anti-MC1R antibodies

Anti-MC1R Antibody EPR6530

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310678
  • Rabbit Monoclonal antibody against MC1R
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400853) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
Assay(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human MC1R was used as an immunogen.
Clone NameEPR6530 IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:500 - 1:1000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IP.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R)
Alternative NameCMM5; MSH-R; SHEP2
Database LinkNP_002377
FunctionMC1R is the receptor protein for melanocyte-stimulating hormone (MSH). It is a seven pass transmembrane G protein coupled receptor that controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Different variations have been identified to correlate with skin and hair color, providing evidence that MC1R is an important component in determining normal human pigment variation (1).
Related Pathway
Melanogenesis
Signaling by GPCR

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WB Image
Western blot - Anti-MC1 Receptor antibody [EPR6530]; All lanes : Anti-MC1 Receptor antibody [EPR6530] at 1/1000 dilution.Lane 1 : A375 cell lysate.Lane 2 : Human melanoma lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti rabbit at 1/2000 dilution.Predicted band size : 35 kDa.
Assay Image
Other-Anti-MC1 Receptor antibody [EPR6530](TA310678); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MC1 Receptor antibody [EPR6530]; TA310678, at a 1/500 dilution, staining MC1 Receptor in paraffin embedded Human melanoma tissue by Immunohistochemistry.

 

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