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Anti-LRP2 Antibody EPR5875
Also for LRP2 (NM_004525)
|A synthetic peptide corresponding to residues in the cytoplasmic domain of human LRP2 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
|Homo sapiens low density lipoprotein receptor-related protein 2 (LRP2)|
|LRP2, low density lipoprotein-related protein 2 or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. LRP2 is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. It also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog, while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in LRP2 cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR) (1).|
Hedgehog signaling pathway
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Western blot - Anti-Lrp2 / Megalin antibody [EPR5875]; All lanes : Anti-Lrp2 / Megalin antibody [EPR5875] at 1/1000 dilution.Lane 1 : Human thyroid lysate.Lane 2 : 293T lysate.Lane 3 : Human adrenal gland lysate.Lane 4 : Caco 2 lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 522 kDa.
Western blot - Anti-Lrp2 / Megalin antibody [EPR5875]; .Predicted band size : 522 kDa.