Anti-LRP2 Antibody, EPR5875

Also for LRP2 (NM_004525)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in the cytoplasmic domain of human LRP2 was used as an immunogen.
Clone Name	EPR5875	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:1,000 - 10,000; IHC 1:100 - 250;
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens low density lipoprotein receptor-related protein 2 (LRP2)
Alternative Name	DBS; GP330
Database Link	NP_004516
Function	LRP2, low density lipoprotein-related protein 2 or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. LRP2 is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. It also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog, while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in LRP2 cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR) (1).
Related Pathway	Hedgehog signaling pathway

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WB Image

Western blot analysis on (A) human thyroid, (B) 293T, (C) human adrenal gland, and (D) Caco-2 lysates using anti-LRP2 RabMAb.

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FITC
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Anti-LRP2 Antibody EPR5875

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data