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Anti-LRP2 Antibody EPR5875
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Also for LRP2 (NM_004525)
|A synthetic peptide corresponding to residues in the cytoplasmic domain of human LRP2 was used as an immunogen.|
|Human, Mouse, Rat
||WB: 1:1,000 - 10,000; IHC 1:100 - 250;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens low density lipoprotein receptor-related protein 2 (LRP2)|
|LRP2, low density lipoprotein-related protein 2 or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. LRP2 is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. It also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog, while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in LRP2 cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR) (1).|
Hedgehog signaling pathway
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Western blot analysis on (A) human thyroid, (B) 293T, (C) human adrenal gland, and (D) Caco-2 lysates using anti-LRP2 RabMAb.