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Anti-GPC3 Antibody EPR5547
Also for GPC3 (NM_001164617)
|A synthetic peptide corresponding to residues in human Glypican-3 was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:50000; ICC/IF: 1:100 - 1:250
|pH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens glypican 3 (GPC3), transcript variant 1|
|DGSX; GTR2-2; MXR7; OCI-5; SDYS; SGB; SGBS; SGBS1|
Entrez Gene 2719 Human
|Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. Glypican-3 can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Mutations in Glypican-3 are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome (1).|
|Druggable Genome |
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Western blot - Anti-Glypican 3 antibody [EPR5547]; All lanes : Anti-Glypican 3 antibody [EPR5547] at 1/10000 dilution.Lane 1 : SH-SY5Y cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : HepG2 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 66 kDa.
Immunocytochemistry/ Immunofluorescence - Anti-Glypican 3 antibody [EPR5547]; TA310545, at 1/100 dilution, staining Glypican 3 in HepG2 cells by Immunofluorescence.