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Anti-GAP43 Antibody Polyclonal

WB(1)

IHC(1)

IF(1)

Gene Name Homo sapiens growth associated protein 43 (GAP43), transcript variant 1 Synonyms: B-50; PP46 Immunogen A synthetic peptide corresponding to residues in the C-term of human GAP-43 was used as an immunogen. Buffer Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt. Clone Name Polyclonal Isotype Species Reactivity Human, Rat Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB, IHC, IF Suggested Dilutions WB: 1:1,000-10,000; Background Growth associated protein GAP43 (B-50, F1, neuromodulin) is a phosphoprotein of the presynaptic membrane involved in synaptic reorganization and neural development. Phosphorylated at Ser41 by protein kinase C (PKC), phosphorylated GAP43 has been correlated to release of neurotransmitters in the mature nervous system (1). Also, GAP43 plays an essential role in the maintenance mechanism of long-term potentiation (LTP) (2). This suggests GAP43 to play a role in synaptic plasticity. For neurons in development or regeneration, GAP43 is a major component of the growth cone, which enables elongation and navigation of developing axons (3). During periods of low activity in neurons, Calmodulin binds to GAP43 when Ca2+ is low, suggesting Calmodulin as a negative regulator of GAP43 (4). Related Pathway

Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • GAP43 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • GAP43 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Gap43 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • GAP43 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Gap43 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens growth associated protein 43 (GAP43), transcript variant 1 as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens growth associated protein 43 (GAP43), transcript variant 1 as transfection-ready DNA Related cDNA Clones • Homo sapiens growth associated protein 43 (GAP43), transcript variant 1 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)