Home All anti-GADD45B antibodies
Anti-GADD45B Antibody EPR1235(2)
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Also for GADD45B (NM_015675)
|A synthetic peptide corresponding to residues in human GADD45 beta was used as an immunogen.|
|Human, Mouse, Rat
||WB: 1:1,000 - 10,000;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens growth arrest and DNA-damage-inducible, beta (GADD45B)|
|GADD45 beta is a member of a group of proteins whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The proteins in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of their protein products is involved in the regulation of growth and apoptosis. These proteins are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth (1).|
MAPK signaling pathway
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Western blot analysis on (A) Jurkat, (B) fetal liver, (C) fetal heart, and (D) A549 cell lysates using anti-GADD45 beta RabMAb.