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Home Antibody All anti-FOXO4 antibodies

Anti-FOXO4 PHOSPHO Antibody EPR2315(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310500
  • Rabbit Monoclonal antibody against FOXO4, pS262 (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
Assay(1)
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Also for FOXO4 (NM_005938)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding serine 262 of human FOXO4 was used as an immunogen. This antibody only detects FOXO4 phosphorylated at serine 262.
Clone NameEPR2315(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY Suggested DilutionsWB: 1:10000 - 1:50000
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens forkhead box O4 (FOXO4), transcript variant 1
Alternative NameAFX; AFX1; MLLT7
Database LinkNP_005929
Entrez Gene 4303 Human
Entrez Gene 54601 Mouse
Entrez Gene 302415 Rat
FunctionFOXO4 is a member of the O class of winged helix/forkhead transcription factor family. It is regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this protein on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia (1). A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity (2).
Related Pathway
TGF Beta Signaling Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-FOXO4 (phospho S262) antibody [EPR2315(2)]; All lanes : Anti-FOXO4 (phospho S262) antibody [EPR2315(2)] at 1/10000 dilution.Lane 1 : Cell lysate from FOXO4 transfected 293T.Lane 2 : Cell lysate from FOXO4 transfected 293T treated with Alkaline Phosphatase.Lane 3 : Cell lysate from non-transfected 293T.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 53 kDa.
Assay Image
Other-Anti-FOXO4 (phospho S262) antibody [EPR2315(2)](TA310500); Equilibrium disassociation constant (KD)..

 

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