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Anti-FOSL2 Antibody EPR4713(2)
Also for FOSL2 (NM_005253)
|A synthetic peptide corresponding to residues near the C-terminus of human Fra-2 was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:100 - 1:500
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for ICC or IHC-P.
|Homo sapiens FOS-like antigen 2 (FOSL2)|
|Fra-2, one of the Fos-related antigens, is promptly expressed after the growth stimulation of fibroblasts, but its induction peak is later than that of c-Fos (1). Fra-2 belongs to the activator protein 1 family of transcription factors, and it regulates the production of extracellular matrix in systemic sclerosis (SSc). It has been demonstrated that Fra-2 is overexpressed in SSc and acts as a novel downstream mediator of the profibrotic effects of TGFß and PDGF. It might be an interesting novel candidate for molecular-targeted therapies for SSc (2). |
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Western blot - Anti-FRA2 antibody [EPR4713(2)]; All lanes : Anti-FRA2 antibody [EPR4713(2)] at 1/1000 dilution.Lane 1 : MCF7 cell lysate.Lane 2 : F9 cell lysate.Lane 3 : PC12 cell lysate.Lane 4 : NCCIT cell lysate.Lane 5 : 293T cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 35 kDa.
Flow Cytometry - Anti-FRA2 antibody [EPR4713(2)]; TA310497 at 1/100 dilution staining FRA2 in permeabilized 293T cells (red). A rabbit IgG was used as negative control (green).