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Anti-FAS Antibody EPR520(2)
|A synthetic peptide corresponding to residues in human CD95 / Fas was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; ICC: 1:50 - 1:100
|Does not react with Mouse. Is unsuitable for Flow Cyt,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens Fas cell surface death receptor (FAS), transcript variant 1|
|ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6|
|CD95 / Fas is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and it has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of CD95 / Fas with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and it is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells.|
Cytokine-cytokine receptor interaction
MAPK signaling pathway
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Western blot - Anti-CD95 antibody [EPR520(2)]; All lanes : Anti-CD95 antibody [EPR520(2)] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Raji cell lysate.Lane 3 : Ramos cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 37 kDa.