Anti-FAS Antibody, EPR520(2)

Also for FAS (NM_000043)

Gene Name	Homo sapiens Fas (TNF receptor superfamily, member 6) (FAS), transcript variant 1
Synonyms:	ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6
Immunogen	A synthetic peptide corresponding to residues in human CD95 / Fas was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR520(2)	Isotype
Species Reactivity	Human, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:50,000 - 200,000; ICC: 1:500 - 1,000;
Background	CD95 / Fas is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and it has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of CD95 / Fas with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and it is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells.
Related Pathway	Adipogenesis Apoptosis Cytokine-cytokine receptor interaction MAPK signaling pathway

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WB Image

Western blot analysis on (A) Jurkat, (B) Raji, and (C) Ramos cell lysates using anti-CD95 / Fas RabMAb.

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Anti-FAS Antibody EPR520(2)

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