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Anti-ESRRG Antibody EPR8100
Also for ESRRG (NM_001134285)
|A synthetic peptide corresponding to residues in human Estrogen-related receptor gamma was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for IHC-P or IP.
|Homo sapiens estrogen-related receptor gamma (ESRRG), transcript variant 4|
|ERR3; ERRgamma; NR3B3|
|Estrogen-related receptor gamma is a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element. The ESRR family is closely related to the estrogen receptor (ER) family. They share target proteins, co-regulators and promoters, and by targeting the same set of proteins, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that Estrogen-related receptor gamma functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation (1). |
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Western blot - Anti-Estrogen Related Receptor gamma antibody [EPR8100]; All lanes : Anti-Estrogen Related Receptor gamma antibody [EPR8100] at 1/1000 dilution.Lane 1 : Human ovary cancer lysate.Lane 2 : Human breast lysate.Lane 3 : Human fetal heart lysate.Lane 4 : Human spleen lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 51 kDa.