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Home Antibody All anti-EIF6 antibodies

Anti-EIF6 Antibody EPR6512(B)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310451
  • Rabbit Monoclonal antibody against eIF-6 (EIF6)
100ul $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human eIF-6 was used as an immunogen.
Clone NameEPR6512(B) IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; FC: 1:100 - 1:500
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC or IP.

Reference Data

Target NameHomo sapiens integrin beta 4 binding protein (ITGB4BP), transcript variant 3
Alternative NameCAB, EIF6, EIF3A, p27BBP, b(2)gcn
Database LinkNP_852134
FunctionHemidesmosomes are structures that link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. eIF-6 binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. It is insoluble and found in both the nucleus and cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits (1).
Related Pathway

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WB Image
Western blot - Anti-integrin beta 4 binding protein antibody [EPR6512(B)]; All lanes : Anti-integrin beta 4 binding protein antibody [EPR6512(B)] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : RAW 264.7 cell lysate.Lane 3 : K562 cell lysate.Lane 4 : 293T cell lysate.Lane 5 : HepG2 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 27 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-integrin beta 4 binding protein antibody [EPR6512(B)]; TA310451, at 1/100 to 1/250, staining integrin beta 4 binding protein in Human colonic adenocarcinoma by immunohistochemistry [Paraffin Embedded Tissues (IHC-P)].

 

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