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Anti-EIF6 Antibody EPR6512(B)
Also for EIF6 (NM_181469)
|A synthetic peptide corresponding to residues in human eIF-6 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; FC: 1:100 - 1:500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for ICC or IP.
|Homo sapiens integrin beta 4 binding protein (ITGB4BP), transcript variant 3|
|CAB, EIF6, EIF3A, p27BBP, b(2)gcn|
Entrez Gene 3692 Human
Entrez Gene 16418 Mouse
Entrez Gene 305506 Rat
|Hemidesmosomes are structures that link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. eIF-6 binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. It is insoluble and found in both the nucleus and cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits (1).|
|Druggable Genome |
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Western blot - Anti-integrin beta 4 binding protein antibody [EPR6512(B)]; All lanes : Anti-integrin beta 4 binding protein antibody [EPR6512(B)] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : RAW 264.7 cell lysate.Lane 3 : K562 cell lysate.Lane 4 : 293T cell lysate.Lane 5 : HepG2 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 27 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-integrin beta 4 binding protein antibody [EPR6512(B)]; TA310451, at 1/100 to 1/250, staining integrin beta 4 binding protein in Human colonic adenocarcinoma by immunohistochemistry [Paraffin Embedded Tissues (IHC-P)].