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Home Antibody All anti-DUX4 antibodies

Anti-DUX4 Antibody E55

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310431
  • Rabbit Monoclonal antibody against DUX4
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC409695) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
FC(1)

OriGene Data

ImmunogenRecombinant proteins, a mixture of two different protein fragments, of human DUX4 were used as an immunogen.
Clone NameE55 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsICC/IF: Use at an assay dependent concentration; WB: 1:1000 - 1:10000; FC: 1:10 - 1:100
Predicted MW Explanation 45 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens double homeobox 4 (DUX4)
Alternative NameDUX10
Database LinkNP_149418
Entrez Gene 22947 Human
FunctionThe DUX4 antibody, clone E5-5, was recently described in the publication called "Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene." (Snider L et al. PLoS Genet. 2010 Oct 28;6(10):e1001181).

DUX4, also known as double homeobox 4, contains two homeoboxes; the repeat-array and open reading frame (ORF) is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries; however, RT-PCR and in-vitro expression experiments indicate that DUX4 has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1. Mutations in DUX4 cause autosomal dominant facioscapulohumeral muscular dystrophy (FSHD) (1).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Dux4 antibody [E55]; All lanes : Anti-Dux4 antibody [E55] at 1/1000 dilution.Lane 1 : Human testis lysate.Lane 2 : HT 1080 cell lysate.Lane 3 : PC 3 cell lysate.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 45 kDa.
FC Image
Flow Cytometry - Anti-Dux4 antibody [E55]; TA310431 at 1/10 dilution staining Dux4 in permeabilized HeLa cells by Flow cytometry (red) or a rabbit IgG as negative control (green).

 

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