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Anti-DOCK2 Antibody EPR6647
Also for DOCK2 (NM_004946)
|A synthetic peptide corresponding to residues near the C-terminus of human DOCK2 was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens dedicator of cytokinesis 2 (DOCK2)|
Entrez Gene 1794 Human
|DOCK2 is a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis (1). DOCK2 plays a critical role in lymphocyte homing and immunological synapse formation by regulating the actin cytoskeleton. It has been shown that DOCK2 deficiency enables long-term survival of cardiac allografts across a complete mismatch of the major histocompatibility complex molecules. DOCK2 is critical for CD28-mediated Rac activation and is required for the full activation of alloreactive T cells (2). |
|Druggable Genome Chemokine signaling pathwayFc gamma R-mediated phagocytosis|
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Western blot - Anti-DOCK2 antibody [EPR6647]; All lanes : Anti-DOCK2 antibody [EPR6647] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Raji cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 212 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DOCK2 antibody [EPR6647]; TA310415, at 1/50 - 1/100, staining DOCK2 in Human lung tissue by immunohistochemistry [Paraffin Embedded Tissues (IHC-P)].