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Anti-DCAMKL1 Antibody EPR6085

WB(1)

IHC(1)

Gene Name Homo sapiens doublecortin-like kinase 1 (DCLK1), transcript variant 1 Synonyms: CL1; CLICK1; DCAMKL1; DCDC3A; DCLK Immunogen A synthetic peptide corresponding to residues in human DCAMKL1 was used as an immunogen. Buffer Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt. Clone Name EPR6085 Isotype Species Reactivity Human, Mouse, Rat Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB, IHC Suggested Dilutions WB: 1:10,000 - 50,000; IHC 1:250 - 500; ICC: 1:100 - 250; IP: 1:10 - 100; FC: 1:10 - 100; Background DCAMKL1 is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinases, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of DCAMKL1 is independent of its protein kinase activity. It is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Furthermore, DCAMKL1 is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities (1). Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of doublecortin-like kinase 1 (DCLK1) Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • DCLK1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • DCLK1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Dclk1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • DCLK1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Dclk1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens doublecortin-like kinase 1 (DCLK1), transcript variant 1 as transfection-ready DNA • Lenti ORF clone of Human doublecortin-like kinase 1 (DCLK1), transcript variant 1 , Myc-DDK-tagged • Lenti ORF clone of Human doublecortin-like kinase 1 (DCLK1), transcript variant 1, mGFP tagged • GFP-tagged ORF clone of Homo sapiens doublecortin-like kinase 1 (DCLK1), transcript variant 1 as transfection-ready DNA Related cDNA Clones • Homo sapiens doublecortin-like kinase 1 (DCLK1), transcript variant 1 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)