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Anti-DCAMKL1 Antibody EPR6085
Also for DCAMKL1 (NM_004734)
|A synthetic peptide corresponding to residues in human DCAMKL1 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100; ICC: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens doublecortin-like kinase 1 (DCLK1), transcript variant 1|
|CL1; CLICK1; DCAMKL1; DCDC3A; DCLK|
|DCAMKL1 is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinases, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of DCAMKL1 is independent of its protein kinase activity. It is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Furthermore, DCAMKL1 is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities (1).|
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Western blot - DCAMKL1 antibody [EPR6085]; All lanes : Anti-DCAMKL1 antibody [EPR6085] at 1/1000 dilution.Lane 1 : Human fetal lung lysate.Lane 2 : NIH3T3 lysate.Lane 3 : SH-SY5Y lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 82 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - DCAMKL1 antibody [EPR6085]; Immunohistochemical analysis of paraffin-embedded Human brain tissue using ab109029 at a dilution of 1/100.