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Anti-CYP19A1 Antibody EPR6293
Also for CYP19A1 (NM_000103)
|A synthetic peptide corresponding to residues in human Cytochrome P450 17A1 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or IHC-P.
|Homo sapiens cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), transcript variant 1|
|ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM|
Entrez Gene 1588 Human
Entrez Gene 13075 Mouse
Entrez Gene 25147 Rat
|Cytochrome P450 17A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. It localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in Cytochrome P450 17A1 are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia (1). |
|P450Druggable Genome Androgen and estrogen metabolismMetabolic pathways|
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Western blot - Anti-Cytochrome P450 17A1 antibody [EPR6293]; All lanes : Anti-Cytochrome P450 17A1 antibody [EPR6293] at 1/1000 dilution.Lane 1 : Human adrenal gland lysate.Lane 2 : SK-OV-3 lysate.Lane 3 : HeLa lysate.Lane 4 : Jurkat lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 57 kDa.Observed band size : 55 kDa .
Immunocytochemistry/ Immunofluorescence - Anti-Cytochrome P450 17A1 antibody [EPR6293]; TA310386, at 1/100 dilution, staining Cytochrome P450 17A1 in Hela cells by Immunofluorescence.