Anti-COPS5 Antibody, EPR1350

Also for COPS5 (NM_006837)

Gene Name	Homo sapiens COP9 signalosome subunit 5 (COPS5)
Synonyms:	CSN5; JAB1; MOV-34; SGN5
Immunogen	A synthetic peptide corresponding to residues in human COPS5 was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR1350	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:1,000 - 10,000; IP: 1:10 - 100; FC: 1:10 - 100;
Background	COPS5 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. COPS5 is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors (1).
Related Pathway	TGF Beta Signaling Pathway

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WB Image

Western blot analysis on (A) NIH/3T3, (B) U87-MG, (C) MCF-7, and (D) PC-12 cell lysates using anti-COPS5 RabMAb.

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Anti-COPS5 Antibody EPR1350

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