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Anti-CD53 Antibody EPR4342(2)
Also for CD53 (NM_000560)
|A synthetic peptide corresponding to residues on the C-terminus in human CD53 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC/IF: 1:500 - 1:1000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens CD53 molecule (CD53), transcript variant 2|
|CD53 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of CD53 has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses (1).|
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Western blot - Anti-CD53 antibody [EPR4342(2)]; All lanes : Anti-CD53 antibody [EPR4342(2)] at 1/1000 dilution.Lane 1 : Raji cell lysate.Lane 2 : PBMC cell lysate.Lane 3 : Jurkat cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 24 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD53 antibody [EPR4342(2)]; Immunohistochemical analysis of paraffin-embedded Human tonsil tissue labelling CD53 with ab134094 at 1/100 dilution.