Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1) or ACO1, is a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. ACO1 was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes (1).
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.