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Anti-ACO1 Antibody EPR7225


Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against ACO1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400799) , 20ug Explanation
100ul 325 3-7 Days
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Also for ACO1 (NM_002197)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human ACO1 was used as an immunogen.
Clone NameEPR7225 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens aconitase 1, soluble (ACO1), transcript variant 2
Alternative NameACONS; HEL60; IREB1; IREBP; IREBP1; IRP1
Database LinkNP_002188
Entrez Gene 48 Human
Entrez Gene 11428 Mouse
Entrez Gene 50655 Rat
FunctionAconitase 1, also known as iron regulatory element binding protein 1 (IREB1) or ACO1, is a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. ACO1 was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes (1).
Related Pathway

* Availability is in business days
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WB Image
Western blot - Anti-Aconitase 1 antibody [EPR7225]; All lanes : Anti-Aconitase 1 antibody [EPR7225] at 1/1000 dilution.Lane 1 : Human thyroid lysate.Lane 2 : HeLa cell lysate.Lane 3 : Human fetal kidney lysate.Lane 4 : HepG2 cell lysate.Lane 5 : T.T. cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 98 kDa.
Assay Image
Other-Anti-Aconitase 1 antibody [EPR7225](TA310167); Equilibrium disassociation constant (KD)..
IF Image
Immunocytochemistry/ Immunofluorescence - Anti-Aconitase 1 antibody [EPR7225]; TA310167 at 1/100 dilution staining Aconitase 1 in HeLa cells by immunofluorescence.


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