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|Native bovine Ubiquitin, conjugated to KLH|
|Human, Monkey, Mouse, Rat, Hamster, Rabbit, Guinea porcine, Bovine, porcine, dog, Sheep, Chicken, Xenopus, Drosophila
||Lot dependent; please refer to CoA along with shipment
|PBS with 0.02% sodium azide.|
|Homo sapiens ubiquitin B (UBB), transcript variant 1|
|RPS27A; UBA52; UBC|
Entrez Gene 7314 Human
Entrez Gene 22187 Mouse
Entrez Gene 192255 Rat
Entrez Gene 696110 Monkey
Entrez Gene 479513 Dog
|This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome. [provided by RefSeq]. |
|Druggable Genome Parkinson's disease|
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Western blot analysis of ubiquitinated proteins in HEK93 cells, using a dilution of anti-UBB.
Ubiquitin visualized using anti-UBB, tested on Bouin's fixed paraffin-embedded backskin sections of transgenic mice.