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Home Antibody All anti-CTNNB1 antibodies

Anti-CTNNB1 PHOSPHO Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA309085
  • Rabbit Anti-ßeta-Catenin (Ser33/37) Antibody (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
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Also for CTNNB1 (NM_001904)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser33/37 conjugated to KLH
Clone Name IsotypeIgG
Species Reactivityhuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000
Buffer100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Purification Affinity Purified

Reference Data

Target NameHomo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 1
Alternative Namearmadillo; CTNNB; MRD19
Database LinkNP_001895
FunctionThe protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Related Pathway
Adherens junction
Adipogenesis
Focal Adhesion
Melanogenesis
TGF Beta Signaling Pathway
Wnt Signaling Pathway

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WB Image
Western blot of human embryonic kidney cell (HEK) lysate showing specific immunolabeling of the ~83k β-catenin phosphorylated at Ser33 and Ser37 (Upper Panel) and a pan β-catenin (Lower Panel). Control is a standard HEK cell lysate. GSK3 is a HEK cell lysate with glycogen synthase kinase 3β knocked down by SiRNA.

 

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