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Anti-ALOX5 PHOSPHO Antibody
Also for ALOX5 (NM_000698)
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser523 conjugated to KLH|
||Lot dependent; please refer to CoA along with shipment
|100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
|Homo sapiens arachidonate 5-lipoxygenase (ALOX5), transcript variant 1|
|5-LO; 5-LOX; 5LPG; LOG5|
Entrez Gene 240 Human
Entrez Gene 25290 Rat
|This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq]. |
|Druggable Genome Arachidonic acid metabolismMetabolic pathways|
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Western blot of rat cortex lysate showing specific immunolabeling of the ~80k doublet of 5-LO phosphorylated at Ser523 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: Î»-Ptase). The blot is identical to the control except that it was incubated in Î»-Ptase (1200 units for 30 min) before being exposed to the 5-LO Ser523 antibody. The immunolabeling is completely eliminated by treatment with Î»-Ptase.